How Long Does Lyrica Stay in Your System?

Since 2005, 16 million people have taken Lyrica. Are you one of them? There are other people like you who take Lyrica or pregabalin to deal with pain or seizures.

While you’re taking Lyrica and while you’re coming off of it, there are some side affects. There’s no reason not to wonder how long those effects will last.

You may be thinking if anti-epileptic drugs like Lyrica can show up on a drug test if you have to go through them for work or the law.

We’ve done the investigation on everything from its start-up time to whether it will appear on a urine test.

Find out more about Lyrica and how long it stays in your body below:

How long does it take for Lyrica to work?

When Lyrica is taken as directed, the capsules are swallowed and go to the digestive tract where they are absorbed. Pregabalin reaches its peak blood concentrations 42–78 minutes (0.7–1.3 hours) after consumption. When Pregabalin 50mg is taken with food, the absorption rate is decreased, although not to the same degree, and the effects and peak concentration take longer to manifest.

At clinical doses, Lyrica doesn’t have a big effect right away. People who have never used it before might feel sleepy or dizzy at most. Lyrica doesn’t start to help you feel better until you’ve been taking it daily for at least two days. It might take Lyrica two to four weeks to help with nerve pain.

Abusers of pregabalin may try different ways to inject the drug into their bodies to speed up the effects and get a stronger high. The powder inside the pills could be broken open and snorted. On a less common occasion, they may smoke it, put it under their tongue, or inject it.

High doses of Pregabalin 75mg for recreational use are usually three to twenty times higher than clinical doses. These high doses do have obvious short-term effects, such as a feeling of euphoria and relaxation that is often compared to being tipsy.

How Long Does Lyrica Cause Effects?

When you take Lyrica 150mg by mouth, it goes to your digestive tract and starts to be absorbed by your body. Side effects, like feeling dizzy or sleepy, can start anywhere from 30 minutes to two hours later.

Some people feel dizzy for up to seven weeks after taking Lyrica. It can last for three to ten weeks before you feel normally again. It’s possible for feeling dizzy and sleepy to last for a long time.

Lyrica 300mg typically takes a few weeks of consistent daily use to begin to reduce pain. Controlling seizures typically occurs more quickly.

You can develop withdrawal symptoms after you stop using Lyrica. This may occur even when you reduce the medication dosage. The moment you stop using Lyrica, the pain alleviation typically ends along with the onset of withdrawal symptoms.

The body and brain effects of withdrawal can include:

  • Agitation
  • Anxiety
  • Confusion
  • Chest pain
  • Delirium
  • Mood changes
  • Tremors

After the final dosage, Lyrica detox’s effects persist for roughly a week. It’s crucial that you let your doctor know if you’re stopping Lyrica due to these side effects.

How Long Does Pregabalin Stay in Different Parts of Your Body?

Understanding the distribution and elimination of pregabalin in various bodily tissues is crucial for comprehending its overall duration in the system:


Pregabalin reaches peak plasma concentrations within 1.5 hours after oral administration. Its half-life in the blood ranges from 6 to 8 hours in healthy individuals. However, This Duration can vary based on individual factors.


The majority of pregabalin is excreted unchanged in the urine within 24 hours of ingestion. However, traces of the drug may be detectable in urine for up to 2-3 days post-administration, depending on factors like dosage and renal function.


Pregabalin can be detected in hair follicles, providing a more extended detection window compared to blood or urine tests. Hair testing can reveal pregabalin (Lyrica 300mg) use for several months after the last dose, making it useful for assessing long-term drug exposure.


Pregabalin is detectable in saliva within hours of ingestion, with concentrations peaking around 1-2 hours post-dose. Saliva testing may offer insights into recent pregabalin use but has a Shorter Detection window compared to urine or hair tests.

Factors Affecting Drug Testing for Pregabalin

If you’re subject to drug testing, whether for employment purposes or legal reasons, several factors can influence the results:

Type of Test

Different drug tests have varying detection windows for Pregabalin 300mg. Urine tests are commonly used due to their wide availability and longer detection window, while blood and saliva tests offer insights into recent use.

Sensitivity of the Test

The sensitivity of the drug test determines its ability to detect low concentrations of pregabalin. Highly sensitive tests may identify the drug even at minimal levels, while less sensitive tests may yield false-negative results.

Timing of the Test

The timing of the drug test concerning your last dose of pregabalin (Lyrica 75mg) is crucial. Testing too soon after ingestion may result in false-negative results, while delaying the test excessively may reduce the drug’s detectability.


In conclusion, the duration of pregabalin presence in your system varies based on individual factors such as metabolism, dosage, and duration of use. Understanding these factors can help you make informed decisions regarding its use and potential implications for drug testing. If you have concerns about pregabalin presence in your system, consult with a healthcare professional for personalized guidance.

FAQs (Frequently Asked Questions)

Q1: Can pregabalin show up on a standard drug test?

Yes, pregabalin can be detected on certain drug tests, particularly urine tests, due to its presence in bodily fluids.

Q2: How long does pregabalin stay in your system for chronic users?

Chronic use of pregabalin may result in its accumulation in bodily tissues, prolonging its presence in the system for an extended duration compared to occasional use.

Q3: Does drinking water help flush pregabalin out of your system faster?

While staying hydrated is essential for overall health, there is limited evidence to suggest that drinking water can significantly hasten the elimination of pregabalin from the body.

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